University of Missouri School of Medicine MU Health School of Medicine
BioDesign Divider

MU Biodesign
and Innovation Program

Attn: Roger de la Torre
One Hospital Drive, DC075.00
Columbia, MO 65211
(573) 882-5609


About Our Fellowship

The MU Biodesign and Innovation Program's (MUBIP) educational goal is to mentor our fellows through the process of successfully bringing innovative medical technologies and health care solutions into the health care market. MUBIP produces high-quality innovative professionals with the desire and knowledge to continue producing new medical technologies within our program, the University of Missouri-Columbia, MU Biodesign affiliates, corporations or through the establishment of new companies.

MUBIP offers a one-year fellowship for three individuals from July 1 to June 30. The three-member fellowship team comprises a physician, engineer and businessperson. Physicians interested in the fellowship need to apply to the Physician Biodesign Research Fellowship. Engineers and business individuals interested need to apply to the Biodesign and Innovation Fellowship. (Note: The application format is the only difference between the Physician Biodesign Research Fellowship and the Biodesign and Innovation Fellowship.) The requirement for the Physician Biodesign Research Fellowship is to have completed two years of residency, usually within a surgical discipline. The requirement for the Biodesign and Innovation Fellowship for the engineer and businessperson is to have completed a master's program. However, other situations, such as business experience in the medical device or health care arena, might be considered. A salary stipend is provided to each fellow.

For more information please contact

Fellowship Structure

Phase 1: (July - October)
Phase 1 begins with an introduction to the biodesign concept, an introduction to MUBIP, orientation to the University of Missouri-Columbia system, tours of the hospitals (both human and animal), engineering departments and other important resources. The fellows obtain clinical observation experience and identify needs by shadowing physicians on a daily basis. This experience is gained through observing cases in the operating room, rounds in the intensive care units and patient floors, rounds in animal clinics and operating rooms, outpatient clinic visits, interviews and interaction with clinicians and physician conferences. Clinical needs are identified and documented throughout the clinical experience. The fellowship team discusses the identified clinical needs and develops potential solutions to fit those needs. The team meets with different faculty involved with MUBIP weekly to broaden their clinical knowledge and understanding from different observations. Weekly meetings with the Biodesign Committee provide a forum to discuss the outcome of the clinical learning experience and the progress of identifying innovative medical technologies.

The fellowship team compiles a list of potential medical solutions into a database. Through filtering, the process of selection for a good clinical idea to move forward, the fellows eliminate idea concepts that do not fit the program's constraints. At this point, the fellows will have a small list of potential concepts. The fellowship team researches items on the list by consulting with faculty and experts and by performing literature and patent searches. In addition to these searches, a market analysis is needed for each device. The fellowship team presents the results of this research to the Biodesign Panel. A report on each device includes a needs statement and a needs specification report. The fellowship team selects the best medical solution concept to focus on for the remainder of the fellowship based on feedback from the panel.

Phase 2 : (November – February)
During Phase 2, the fellowship team focuses on product design and prototype development. Through observation and discussion, the fellows gain knowledge from experts in engineering on campus. This is applied to the process of prototype development and design. The team is mentored by engineers to develop a prototype and final product for a new medical technology. A prototype of the final design should be completed by the end of phase 2. If applicable, the process to protect intellectual property begins during this phase. The fellowship team works with the University of Missouri-Columbia Office of Intellectual Property Administration to protect the project or idea and MU's ownership of the new medical technology.

Phase 3 : (March – June)
The final phase provides the fellowship team the information needed to create a final business plan or development plan for the new medical technology. During the previous months, the team identified clinical needs and developed concepts to solve the needs and continued to progress the idea towards a marketable device or medical application. Learning about entrepreneurship, market analysis, understanding venture capital funding and angel funding are important concepts in Phase 3 and complete the biodesign simulation. Depending on the team and the project, new company development is taught, discussed and possibly implemented. The final task for the team is to present the selected idea as a complete product and future ideas to the Biodesign Panel.


The MU Biodesign and Innovation Program (MUBIP) provides a biodesign lecture series each academic year to fellows, faculty and staff. The daily lecture series involves permanent faculty members of all MUBIP partners, speaking on a variety of topics. The fellows are also invited to specialty seminars throughout the campus.

In addition to the daily lectures, guest speakers from different areas of the biodesign process are invited to MUBIP. Outside experts, such as inventors, medical device experts, venture capitalist, executives, and entrepreneurs provide the fellows, faculty, and staff a network of individuals and knowledge in biodesign.

Fellow Alumni

MUBIP 2014-2015 Fellows

Jaya Ghosh, PhD

Orr Hadass, MS Biomedical Engineering

Jaya received her Bachelor's degree in Instrumentation & Control Engineering from Manipal Academy of Higher Education in 2005. During her fourth year, she worked on a project to develop Fuzzy Petri Net models of discrete event systems. In addition, her undergraduate research experience involved detailed analysis and study of Process Instrumentation and Control System of LCW Plant for Superconducting Cyclotron at the Super Laboratory, CPIESG, Department of Atomic Energy, Variable Energy Cyclotron Centre in Kolkata, India.

From 2005-2007, Jaya worked as a Software Engineer at Infosys Technologies Limited in India. In 2013, Jaya completed her PhD degree in Biological Engineering with an emphasis on Electrophysiology and BioMEMS at the University of Missouri-Columbia. Her dissertation focused on integration of single-cell electropermeabilization together with electrochemical measurement of quantal exocytosis on microchips. Among other techniques, her research work involved Lab-on-a-chip Technology and Instrumentation, Microfabrication, Amperometry/Cyclic Voltammetry, Primary Cell Culture, Single-cell Electropermeabilization, and Patch Clamp Electrophysiology. After completion of her graduate degree, Jaya continued working as a Postdoctoral Fellow to complete her work on Cell-based Electrochemical Detection of Botulinum Neurotoxin.

Jaya hopes to utilize her wide interests in healthcare, science and engineering to innovate biomedical technologies that can improve the field of medicine. In her free time, Jaya enjoys traveling, photography, books, and music.

Yaw Sarpong, MD, MBA

Yaw Sarpong, MD, MBA

Dr. Yaw Sarpong was born in Kumasi, Ghana but grew up in Atlanta, GA. He obtained his undergraduate degree in biological sciences at Emory University in 2003 and spent a year doing research in physiology at Emory. In 2004, he started his medical school training at Vanderbilt Medical School and graduated in 2008. He then went to start his neurosurgical residency at University of Washington and subsequently transferred to the University of Missouri in 2013. He is currently in his 5th year of training. In 2014, he obtained his executive MBA in healthcare from George Washington University. His interests range from developing novel technologies to solve medical problems as well as developing ways of improving, diagnosing, and treating neurosurgical diseases such as tumors, AVMS, aneurysms, functional concerns, and spinal abnormalities. In his spare time, Dr. Sarpong likes to read, write, exercise, travel, and spend time with his wife and two dogs.

Ellie Koehly, MBA

Ellie Koehly, MBA

Ellie graduated summa cum laude from the University of Missouri-Columbia with a BA in Biological Sciences and a Minor in Public Service and Leadership. During her time as an undergraduate, she volunteered for several non-profits in the Columbia community including Boone County Family Resources, Boone County Council on Aging, Special Olympics Missouri, and MU Relay for Life. In addition, she served as Philanthropy Chair for her sorority and directed fundraising efforts that resulted in over $40,000 being raised for St. Jude Children’s Research Hospital.

Following graduation in 2012, Ellie complemented her science background with a Master’s in Business Administration from the University of Missouri Crosby MBA program. Throughout her graduate career, she has continued to stay passionate about the life science and healthcare fields. Her work includes teaching a Biology lab for non-majors at the University of Missouri, as well as a summer internship at St. Jude Children’s Research Hospital in Memphis, TN. In her last semester of graduate school, Ellie interned for Cultivation Capital, a St. Louis venture capital firm, working on their life sciences due diligence team.

Ellie always knew she wanted a career that allowed her to utilize both her passion for science and business. She is thrilled to be a part of this fellowship program and hopes to discover innovative biomedical technologies that make a difference in the lives of others.

Commercialization Fellows

Kyle Rood, MS Biological Engineering

Kyle Rood, MS Biological Engineering

Kyle attended the University of Missouri-Columbia and received a B.E. in Biological Engineering, earning Magna Cum Laude honors after a short stint in the School of Journalism. During his time as an undergraduate, he participated in intercollegiate sports and was a varsity member of MU's track and cross country programs for five years.

Kyle began research in Dr. John Viator's photoacoustic lab as an upperclassman and worked on a system to detect malignant cancer cells by interrogating blood specimens with a laser. The project has been successful, and allowed him to garner multiple patents and an authorship.

During his time in the graduate program at MU, Kyle continued research in the photoacoustic lab to perfect the early cancer detection system and earn a Master of Science in Biological Engineering.

As an MUBIP fellow, Kyle looks to couple the dedication that running has provided with his interest in engineering effective solutions to foster a productive and innovative experience in the field of healthcare.

Adam Rau, MBA

Adam Rau, MBA

Adam came to the University of Missouri-Columbia in 2001 to pursue a degree in business management. Adam has always been a True Tiger and destined for Mizzou. Both parents and all three siblings followed suit for a combined total of nine degrees. From medicine to journalism to physiology, the legacy extends back three generations on both sides of the family.

Following graduation in 2005, Adam started a career in business and explored many options before developing a successful student-housing business. Starting with one house and roommates in 2003, the company has grown to 30 properties and more than 100 beds under management.

Adam began the University of Missouri Crosby MBA program in 2011. A course called Launching a High Growth Venture sparked Adam's initial interest in biodesign.

Facilitated by the MU Life Science Incubator, the program explores the early phases and launching of biodesign companies. Adam was also a member of the Allen Fund, a cross-disciplinary, student-run angle program. This fund invests in local high growth ventures with a specialty in biotech start-ups. Adam's ultimate goal is to develop and run a biodesign start-up.

MUBIP 2013 - 2014 Fellows

Orr Hadass, MS Biomedical Engineering

Orr Hadass, MS Biomedical Engineering

Orr received his bachelor's degree in biomedical engineering from St. Louis University in 2009. During his fourth year, he worked in a capstone project team to develop a rotating mandrel for electrospinning — an early stage prototype capable of creating biocompatible polymer tubes used as artificial vascular implants. In addition, his undergraduate research experience involved the construction and analysis of CT scan-based finite element models for detection of electrode placement during iliosacral screw insertion.

In 2012, Orr completed his MS degree in pathology with an emphasis in neuroscience at the University of Missouri-Columbia. His graduate thesis focused on traumatic brain Injury and the therapeutic potentials of an experimental protease inhibitor in reducing secondary brain damage at the cellular and molecular levels. Among other techniques, his research work involved brain surgeries on mice, advanced imaging, histology, proteomics and behavioral methods for assessment of brain injury in treated versus control groups.

Orr hopes to utilize his wide interests in healthcare, science and engineering to discover innovative biomedical technologies that can improve the field of medicine, as well as generate profitable business opportunities. In his free time, Orr enjoys traveling, cooking, live music, and he is a devoted sports fan.

J. Wesley Rayburn, MD, BS Electrical Engineering

J. Wesley Rayburn, MD, BS Electrical Engineering

When Wes graduated from high school in 1998, he already had a full-time job with benefits in the computer industry and didn't see any need to attend college. He changed his mind a couple of years later, however, and enrolled at the University of Mississippi to study electrical engineering in January 2000.

During his time as an undergraduate, Wes worked at the National Center for Physical Acoustics, which is located on the Ole Miss campus. He participated in animal research and tested the use of high-intensity focused ultrasound to cauterize internal bleeding. During this time, he became interested in the medical field. Wes earned his bachelor's degree in electrical engineering in 2005, graduated summa cum laude and received the Taylor Medal, which is the highest academic honor given by the university. He entered the University of Mississippi Medical School in Fall 2005.

After graduating from medical school, Wes did his intern year of residency in general surgery at Mizzou before beginning his residency in physical medicine & rehabilitation, where he earned a reputation for his untiring dedication to efficiency and improving every aspect of the program as well as hanging a disco ball in the residents' room and having Friday afternoon dance parties.

During his medical training, Wes never lost touch with his engineering roots or his childhood dream of becoming an inventor. He keeps a notebook in his pocket to write down his ideas for new medical devices and for improving efficiency in everything. He is thrilled for the opportunity to participate in the biodesign fellowship and bridge his medical and engineering training in a new way.

MUBIP 2012 - 2013 Fellows

Clint Matthews, MBA

Clint Matthews, MBA

Clint came to the University of Missouri-Columbia in 2000 to pursue a degree in Atmospheric Science and his dream of playing Division I college football. He was able to accomplish both of those feats and graduated in May 2005.

Clint developed a keen interest in business during his time in undergraduate college, and after graduation, he started working at a local retail lumberyard. Clint managed $1 million in inventory and eventually developed an online store for the company,

In 2010, Clint decided to get an MBA at MU and became acclimated to the biotech startup scene through Management 8550, "Launching a High Growth Venture." He worked with a team to prepare a business plan for NanoCine LLC that received first place in the Show-Me Business Plan competition. His goal is to be the CEO of his own biotech company.

James Galloway, MD

James Galloway, MD

Dr. James Galloway is a fellow in Missouri University's Biodesign and Innovation Program (MUBIP) tasked with identifying and taking to market innovative medical technologies. Dr. Galloway is adept in the healthcare innovation area because he has previously worked with Emory University's Office of Technology Transfer (OTT) in Atlanta, Georgia, and has developed a urological device with the Emory healthcare system.

James trained as a preliminary surgical resident at the Emory University Hospital system and gained broad clinical experience with an array of medical ailments, procedures and outcomes. This experience prepared James for a career in medical innovation, and his early research focused on a medical device that is designed for the treatment of stress urinary incontinence, which he co-invented and patented. The product holds international patents in the United States, Canada, Japan and the United Kingdom and has plans for international distribution.

Dr. Galloway obtained his Bachelor's in Chemistry from Emory University in Atlanta, Georgia; a Medical Degree from St. Matthew's University in Grand Cayman, British West Indies; and a Master in Health Administration from St. Joseph's College in Standish, Maine.

MUBIP 2011 - 2012 Fellows

Khushbu Jain, MBA

Khushbu Jain, MBA

Khushbu received a B.E. degree, magna cum laude, in mechanical engineering from S.G.S. Institute of Technology, India. Immediately following graduation, she worked as a management trainee at Tata Motors, a leading automobile company in India. She worked across several departments, Vendor Management, Quality Management, Supply Chain and Logistics Management, Utilities Management, Procurement and Human Resource, to name a few.

After working on a project for the "world's cheapest car", inspired to innovate and determined to start her own company she left to attend Business School at University of Missouri where she graduated with a concentration in Management and Analytics. During the course she also worked as a strategy consultant advising clients from several domains including retail, telecommunication and engineering services, on doing new business development and process optimization for competitive sustainability.

She took a detour from automobiles to biomedical engineering through launching a high growth venture course during her MBA. She worked with a team to prepare a business plan for EternoGen, and won the Show-Me business plan competition. Eternogen is a start-up medical device company founded by researchers at the University of Missouri and provides superior collagen-based products for minimally invasive surgical applications through the utilization of novel nanotechnology.

Khushbu wants to combine her two passions: entrepreneurship and engineering to drive innovation towards creating low cost medical devices and processes bringing down the overall healthcare cost. She is also passionate about "green" OR and reducing waste and the carbon footprint of hospitals.

In her free time, she loves to travel. Khushbu is also an avid reader and enjoys running, road biking and (very recently) canoeing.

Joshua Arnone, PhD

Joshua Arnone, PhD

Joshua Arnone, son of Larry and Susan Arnone, was born in Oak Grove, MO, where he completed his K-12 education. Upon graduation, he moved to Columbia, MO, where he attended the University of Missouri in order to obtain a BS in mechanical engineering. His undergraduate research experience with computer simulation of the lumbar spine led to his strong desire to apply his degree to the improvement of healthcare. He continued his education at the University of Missouri on order to obtain a PhD in mechanical engineering with an emphasis in biomechanical engineering. During this time he developed a systematic, simulation-based approach for the design and optimization of fixation devices used in orthopedic trauma surgery. He is currently co-authoring a textbook based on this topic. In addition, he and his wife, Annie, are youth directors at a local church.

Charles Sweat, Jr. MD

Charles Sweat, Jr. MD

Charles Sweat, Jr. completed his undergraduate studies at Kentucky State University in 2003 with a dual bachelor's degree in Chemistry and Biology. He graduated from the University of Louisville School of Medicine in 2008. Charles subsequently went on to East Carolina University in Greenville, NC where he did his general surgery internship. Charles then completed his second year of general surgery residency at Medical University of South Carolina in Charleston, SC. Once the MU Biodesign and Innovation Fellowship is over, Charles plans on completing the last three years of his general surgery residency.

MUBIP 2010 - 2011 Fellows

Miranda Shaw, PhD

Miranda Shaw

Miranda N. Shaw received her Ph.D. in biomedical engineering from the Mayo Graduate School in Rochester, MN.  She investigated the role of the spinal vertebral endplate in delivering nutrients to the intervertebral disc.  Her dissertation included developing a validated, three dimensional, nonlinear, poroelastic, T11-sacrum finite element (FE) model.  Utilizing the FE model, the aging and degeneration process of the cartilaginous vertebral endplate was simulated to further understand disc degeneration.  Balloon kyphoplasty in an osteoporotic spine was also modeled to investigate the risk for adjacent vertebral body fractures.  Miranda also holds an M.S. degree from the University of Toledo in bioengineering where she designed and evaluated artificial lumbar facet joint replacement systems.  She obtained her B.S. degree from Ohio Northern University in mechanical engineering.   

Miranda has extensive experience in biomechanical cadaveric testing for implant design and efficacy and motion analysis.  Her research focus is in spine and orthopedic computational biomechanics.  Miranda has also mentored several high school and graduate students.  She has developed courses in biomedical engineering principles and finite element analysis for the graduate and professional level.  Miranda has been elected to membership in Sigma Xi and the American Association for the Advancement of Science.  She currently acts as a reviewer for several journals and conferences. 

Xandra Sifuentes, MBA

Xandra Sifuentes

Xandra Sifuentes received her BS degree in computer science from the University of Missouri in 2004.  Xandra was a flight controls engineer at Honeywell International in Olathe, Kansas immediately following graduation.  She then worked at Garmin International in Olathe, Kansas as a software engineer in the aviation department.  She worked on the G1000 all- glass integrated avionics suite and was promoted to an airframe lead position.  Xandra returned to the University of Missouri in 2008 as a full-time student in the Crosby MBA Program.  While in the program, she had a graduate assistantship as an entrepreneurial scholar at the Missouri Innovation Center.  Xandra had the opportunity to research for multiple start-up companies at the Life Science Business Incubator at Monsanto Place and became familiar with the entrepreneurial world.

Through the high-growth venture course in the Crosby MBA Program, Xandra worked with a team to write a business plan for a medical device that was invented through the MUBIP program.  Her team won the Show-Me Business Plan Competition.  Dr. Anthony Harris and Rebecca Rone were two of the 2008-2009 MUBIP fellows who had invented the medical device, which is a laparoscopic hand instrument.  They invited her to join their management team to form a company based around the laparoscopic hand instrument.  They all co-founded Adroit Motion, LLC, along with Brad Snow, a PhD candidate in mechanical engineering. Xandra and Brad competed in the 2010 Rice Business Plan Competition in April and won $24,100 in cash prizes, including the NASA Earth/Space Engineering Innovation Award and the Pearland Spirit of Entrepreneurship Award.  Xandra graduated from the Crosby MBA Program in May and is currently the CEO of Adroit Motion.  Adroit Motion is working towards prototype development of the laparoscopic hand instrument.  Through the 2010-2011 MUBIP fellowship, she looks forward to gaining more knowledge of surgical procedures, learning rapid prototyping skills, and advancing her ability to write effective business plans.

Michael Barnett, MD

Michael Barnett

Michael Barnett attended medical school at UT San Antonio, performed his internal medicine residency at UT Southwestern in Dallas, and is completing cardiology fellowship at Vanderbilt Medical Center.  His other training includes an MBA from the University of Houston and prior employment as a medical reviewer of cardiovascular devices at the FDA.  He served in the Air Force as a flight surgeon for 4 years and remains a Major in the inactive reserves.  He will continue his training in interventional cardiology and medical device development.


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